A biologically “old” breast cancer subtype in a very young woman: a plea of ignorance

Marcin Sniadecki, Magdalena Krajewska, Maria Stasiak, Aleksandra Walkiewicz, Pawel W. Guzik
January 3, 2025 by
Medisfera

CASE REPORT:

A 27-year-old patient, a physician by profession, attended a gynecologist for a first ultrasound (US) breast examination. Until then, she had no oncological burdens or chronic diseases, had been using hormonal contraception (HC) for 11 years, and had not performed breast self-examination. On US examination, an oval lesion in the right breast (6:30), assessed according to the Breast Imaging Reporting and Data System (BIRADS) score 3, was detected and a follow-up examination was recommended for 6 months’ time. At the follow-up examination after 7 months, the lesion was classified as BIRADS-US-4b (Fig. 1). The patient was referred for a core-needle biopsy. Histopathological examination of a specimen revealed invasive breast carcinoma of no special type G-1 [World Health Organization (WHO): invasive breast carcinoma of no special type (NST)] luminal A phenotype (cT1c, cN0, cMx). Then an magnetic resonance imaging was performed which confirmed the presence of a 16 mm lesion suspected for malignancy. At the patient’s request, breast-conserving surgery with adjuvant radiotherapy was rejected, and instead, the surgical treatment was subcutaneous mastectomy with reconstruction (Fig. 2). Hormone therapy with tamoxifen and goserelin was then commenced.

Full text link